Detective Inspector Greg Lestrade is an inspector with New Scotland Yard. He often requires Sherlock Holmes' assistance to help with difficult cases. Greg has been affiliated with Sherlock for the better part of five years, but he still does not know everything about the consultant's antics and is therefore frequently surprised at his actions.

Greg has respect for Sherlock and seems to possess none of the animosity his team has. He tries to get his team to cooperate with Sherlock whenever possible, even when Sherlock is being insulting. Despite this, he is often frustrated by Sherlock's cryptic deductions and lack of explanations for his conclusions, as well as his constant insults.