George had a difficult childhood, his mother, Benny, is blamed for much of the abuse and jokes that are often made about how she treated him. George initially believed Manny, his father, was dead, but learned he was actually alive from his aunt Cecelia Lopez. He and his mother were spotted by Cecelia during a trip to a grocery store, of which her mom fled upon being seen. When Manny sends George a check to help him out of financial trouble, George goes to see him in Phoenix, and ends up punching him in Benny's honor

As a boy, George enjoyed playing guitar and baseball, in his teens, he started a heavy-metal band with Ernie, His Best Friend, and other friends called "Dos Bad Asses," they won battle of the bands at school by lighting their instruments of fire, but only the first round and making the curtains in the auditorium fire-proof. Throughout grade school, he and Ernie had the reputation of being outcasts or "unpopular." At one point, George learned Angie's ex-boyfriend dumped her before meeting him, making him think she "dropped a level" so she wouldn't get dumped again. Howeverthey later learn that Angie's father Vic Palmero paid him off with $10,000.

George was very unpopular in high school. His only friend in school was his best friend Ernie Cardenas. When he graduated high school, he married Angela Palmero. They have two children together; a daughter Carmen Lopez and a son, Max Lopez. They have been married over 20 years.