Sakura is the youngest daughter of Sumeragi and Ikona and the youngest child of four in the Hoshidan royal family. According to Ryoma, shortly after her birth, her parents named her after a cherry blossom tree that bloomed beautifully every spring. Originally having another sibling in Corrin, Sakura lost them when they were kidnapped as a young child and raised in Nohr. Rumors spread throughout the castle that Sakura was supposedly the original target, but Ryoma had denied these notions to her. Still, this event had an effect on her personality, making her meek and timid. Shy and timid by nature, Sakura is very polite to others but is prone to stuttering during her conversations, a fact that becomes especially prominent when she is nervous. She tends to be very easily intimidated when confronted with unfamiliar situations existing outside her comfort zone. These traits of hers particularly stand out when she is compared alongside her older siblings, all of whom are relatively more confident, self-assured and sanguine. Complementing her shy demeanor is a heart of compassion and kindness, a fact that has led to her devoting her life towards the cause of providing healing aid to others in order to alleviate their suffering. Her gentle demeanor and benevolent heart makes her the best at healing out of everyone in the army.

Hidden beneath the folds of Sakura's meekness is a strong will, one that emerges when she is tried by situations that threaten to endanger the lives of her loved ones. She has red hair and red eyes.