Alcina Dimitrescu/Lady Dimitrescu Resident Evil

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Much of Lady Dimitrescu's past remains a mystery. However, she is believed to have been born around 1914, as she became a mutant at the age of 44 around the late 1950s, and seems to have stopped aging in her mid-forties. Prior to joining the Four Houses, Dimitrescu was a jazz singer under the name "Miss D," where she would frequently sing with a band known as the Pallboys. Alcina would later inherit a specific disease in her blood from one of her ancestors, one that is quite similar to Progenitor Virus symptoms-wise. Because of this, she was taken into the village, where she survived being infected with the Cadou parasite and was given regenerative capabilities. She rules over a large castle as the matriarch of the Dimitrescu family, living with three women whom she considers her daughters, Cassandra, Bela, and Daniela.

Alcina mutated the three women, who survived and became vulnerable to cold temperatures due to their mutated form, which now consists of flies spawned from Cadou eggs injected into their original human bodies. She, like much of the inhabitants in the area, is a member of a dark cult that serves the being known only as "Mother Miranda," to whom she has loyalty but is not also above acting on her own accord against Miranda's wishes. It was Mother Miranda who infected her with the Cadou parasite, giving Alcina a host of extraordinary powers at the cost of needing to consume large amounts of human blood to sustain herself due to her blood disease.

Although Mother Miranda saw Alcina as a perfect candidate for a vessel for her late daughter Eva, the cult leader judged her as imperfect due to her insatiable thirst for blood. Alcina would become a member of the Four Houses alongside Karl Heisenberg, Donna Beneviento, and Salvatore Moreau, serving Miranda under their homes in the village. Despite the alliance between the four houses, Alcina frequently clashed with Heisenberg, seeing him as nothing but a child.

The Dimitrescu Castle became infamous, as many servants who came there wouldn't return, and the villagers came to see the castle as a place of blood and death and would avoid the area unless under extreme circumstances. Alcina would also use the blood of her victims to create a wine called Sanguis Virginis and would often infect her victims, who would become known as the Moroaicǎ and the Samca. Most of the Moroaicǎ were possibly former servants, considering that the Dimitrescu family was known to be replacing maidens through the years.

Some of these maidens that were turned attempted to escape, most notably Ingrid, who was murdered and turned by Alcina when she attempted to leave the castle for the courtyard. In addition, Alcina feared that she would be harmed by the dagger of deathly flowers and had it hidden in the family crypt while also having all the windows in the castle shut to protect her daughters.