Fifi is a young female skunk. She attends Acme Looniversity and lives in Acme Acres. Fifi is based on her mentor and favorite teacher, Pepé Le Pew.

Her fur is purple and white, instead of a normal skunk's black and white, and she keeps a Cadillac pink bow tied to her hair which causes it to fall over one eye, giving her a sultry, coquettish look. She has a massive tail, nearly twice the size of her own body, which is one of the sources of her powerful odor. She uses her tail for a number of things, including a pillow, pom-pom, baseball bat, furry boa, or a snare for some luckless "suitor."

Fifi lives alone in an abandoned pink Cadillac at the Acme junkyard, often lounging on her bed, listening to music, talking on the telephone, reading romance novels, snacking on bon-bons, or waiting for a potential love interest to come her way.

Like her mentor, Pepé, Fifi is French and very flirtatious. She speaks in a French accent, mainly speaking English with a few French words. She also shares the same faults as her idol; intense skunk-odor and an inability to take "no" for an answer when pursuing the romantic object of her choice. When she falls in love, she loses all self-control and will not allow anything to stop her from literally capturing her prey. The skunkette's fumes can be lethal. She pursues her would-be suitor with reckless abandon. She'll do anything to snare her prey. She buys new clothes and expensive perfumes, but nothing seems to work. She never seems to get the guy. Love brings out the smelly aroma in Fifi.

Fifi's putrid stench is powerful enough to melt solid steel, and the more she falls in love, the stronger her stench gets. However, Fifi's musk only comes into play when she is attracted to someone, thus allowing her to interact with others. Fifi is also taken in a somewhat sympathetic light, for she, alone, longs for a lover, leaving many others to feel sorry for her. Also, Fifi realizes she has a foul odor and often uses it to her advantage during desperate situations. For instance, she can wield her tail like a machine gun to fire clouds of musk at others. Her smell can be erased by tomato juice, but the effects are only temporary and can be reversed quickly by washing the tomato juice off.

Fifi is somewhat depicted as a bimbo. Being so, she can easily be tricked into anything. Fifi is also referred to as being something of a feminist and believes that there's nothing a boy could do that she couldn't do herself. However, her remarks toward boys are usually very affectionate and amusing. For instance, Fifi has affectionately remarked, "Leettle boys are such children!," or "Intelligent boys are such a tease!"