Albert is the main antagonist through most of the Resident Evil series. Originally part of a group of special "Wesker" children organized and supervised by the Umbrella corporation, Albert grew up as one of its researchers and later led a group of S.T.A.R.S members to their doom. When it failed, he nearly died being impaled by a Tyrant but a strain of the progenitor virus inside Albert brought him back from the brink and he escaped. Since then, his small allegience to Umbrella severed entirely and he acted solo. He now concocted plans to steal various samples of viruses from Umbrella's different facilities as the corporation slowly crumbled. The mysterious organization he leads centers around his overall plan for world conquest using a new virus he helped manufacture called Uroboros, intending to rule the new world order as its God.

Wesker is a middle aged man and commonly is seen wearing dark shades almost all the time which conceals his red eyes underneath, his hair is blonde and combed back. Normally he's seen wearing dark clothing like a buttoned shirt with matching pants and boots, sometimes wearing a dark coat as well.

Due to the Progenitor virus inside him and being "Revived" after being impaled by a Tyrant, it granted him superhuman abilities primarily great agility, strength and durability. His other greatest asset is his intelligence and great manipulation skills. He even underwent training while working for Umbrella and STARS which he had great combat and weapon skills.