Lester is the tech mastermind behind many of Micheal, Franklin and Trevor's schemes. He is an old and crippled friend of Michael De Santa and helps him throughout his criminal career, including his heists which often involves their associates Trevor Philips and Franklin Clinton as well. He suffers from a wasting disease that has gradually worn down his motor skills during his life, leaving him wheelchair-bound. However, he can walk short distances with the use of a cane. He also suffers from asthma.