On Earth-928B in 2099, Miguel O'Hara is the superhero "Spider-Man", a human mutate with retractable talons, fangs, and enhanced strength that he used to fight crime in his home of Nueva York, along with a spider-inspired costume and laser web shooters. He works closely with his A.I. assistant LYLA, who develops many of his gadgets and weaponry for his work as Spider-Man.

Once a more sarcastic and casual man, Miguel O'Hara was emotionally traumatized after he failed to save an alternate reality from destruction after breaking its canon. He became cold, irritable, and obsessive, working himself to the bone to preserve the canon and stability of the Web of Life and Destiny at any cost. He is trusting of very few, and fiercely critical of those who seek to join his Spider Society.