Sweet Tooth's design in the TV series matches his Twisted Metal: Black and 2012 appearances the most. There are subtle design changes like the mask having both eye holes as well as longer hair, but the most notable is that he lacks his trademark flaming hair for most of the series. He also carries around a machete, which is taken straight from Twisted Metal (2012).

During his show, Sweet Tooth dresses up in a pink tuxedo based on his appearance in Twisted Metal III, mostly resembling his unlockable alternate costume from PlayStation All-Stars: Battle Royale.

Marcus Kane was born at an unknown period of time, the son of Amy Kane and a father who worked as a taxi cab driver. Marcus’ father was arrested at some point in time, leading to custody of Marcus going to Amy.

Before the apocalypse, a young Marcus Kane was the child star of a popular sitcom called “Two Scoops” which was enjoyed by many, playing a boy named Lenny Scoop who ran an ice cream shop with Meemaw Scoop, Eventually a new character named Billy was added, a dog who became a hit with the audience so much that the show was renamed “Billy & Two Scoops”, which made Marcus jealous. Billy’s popularity was so huge that it could be compared to Steve Urlel’s immense popularity on Family Matters, and his fanbase grew to be twice as large as Lenny’s. Marcus expressed this jealousy to Amy and his stepfather Wesley, but was ignored by the both of them.

In 1991, after arguing with his stepdad, Marcus went on stage to film a new episode of the show. His performance was met with basically no reaction from the audience, but the appearance of Billy the Dog was met with laughter and applause. Feeling overshadowed once again, Marcus took the knitting needles from his co-star and brutally killed Billy in front of the audience and director, much to their horror. He was nicknamed “Needles Kane” as a result of this incident, arrested and sent to Blackfield Asylum a year later in 1992, where he was imprisoned for the next 10 years until the apocalypse started in 2002. Marcus later escaped along with several other inmates, later tracking down Amy and Wesley and trapping them in his cell where they remained until their deaths (presumably due to starvation).

Sometime later Marcus; now known as Sweet Tooth, settled in a Lost Vegas hotel with his childhood best friend Harold. Sweet Tooth soon became the ruler of the city as a notorious serial killer who drove around in an ice cream truck. becoming feared by many.