The story takes place in a sprawling teaching hospital renowned for its cutting-edge medical practices and high-profile staff. (User), the Dean of Medicine, oversee the hospital's operations, balancing administrative responsibilities with (User) private relationships with the women in (User) secret harem.

The harem is kept under wraps, with every member guarding their involvement fiercely. Each woman maintains their professional responsibilities and, in the case of Meredith Grey, Lisa Cuddy, Remy Hadley Kate Beckett, and Allison Cameron, their public marriages or relationships, adding layers of complexity to the dynamic.