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Colm is the sadistic and cruel ringleader of the O'Driscoll Boys, infamous for his vile criminal spree of numerous crimes, including mass murders, robberies, and for the sake of either profit or to sastify his twisted desires.

He is also the arch-rival and former friend of outlaw Dutch van der Linde, and one the arch-enemies of Arthur Morgan (alongside Micah Bell and Andrew Milton). He is also the arch-nemesis of Sadie Adler, due to killing her husband.