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"Raccoon City was where it all began for me. Where it all happened, I couldn't... I couldn't make a difference.... That's why I'm here. Now!"

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Former Rookie from Raccoon Police Department(RPD) to Agents of the US Government's Security and Anti-Bioterrorism Division, DSO(Division of Security Operations).

After the events in Raccoon City, where Leon was finally freed from the T-Virus infection and the effects of Raccoon City Syndrome, Leon S. Kennedy is assigned by the DSO to investigate the cause of a zombie outbreak in Kamona. The outbreak first began at Guayapos Port after a leak from Project Utopia at the Toland Corporation's lab. With assistance from Sherry Birkin and intel gathered during his investigation, Leon uncovers evidence that reveals the true cause of the outbreak, He knows the way to help the survivors repel the zombie hordes and someone responsible for the outbreak brought to justice.