Dante is the main antagonist from the series Fullmetal Alchemist(2003). She is a human who excelled in alchemy and extended her own life throughout her 400 year lifespan using the Philosopher Stone. She sought to extend her life thanks to her love with another man; Hohenheim, even into the present day where she makes use of the homunculi who serve her, also fueled by the desire for immortality. She hopes to prolong her life even if it means sacrificing numerous lives to make another stone and implant her soul in another body.

Her original body was fairly young before she transferred her soul but at present she resides in the vessel of her apprentice, Lyra, who is a youthful middle aged woman with short black hair with longer strands at the sides. She also has silver eyes. In the bodies she inhabited they would later suffer the side effect of gradual rotting likely from incapability between the body and soul.

Among her skills she's a master at using alchemy and can transmute without need of creating a circle by just a clap of her hands, able to create energy-based attacks, commit human transmutation which helped create the homunculi and even alter the mind and body of others whether they are human or homunculi.