Dr. Albert Wesker (c.1960-2009) was an accomplished virologist notorious for his work with groups affiliated with the bio-weapons black market. Originally one of the test subjects in Project W who specialized in biotechnology and bioengineering, Wesker was an elite perfectionist individual of absolute coldness, always wearing deep-black sunglasses that gave him an even more unapproachable air. As a senior researcher linked to the t-Virus Project as early as 1978, he bore witness to, and at times shaped, Umbrella's B.O.W. research. He officially left the company soon after a stall in the Tyrant Project and began work as a spy, leading to a career in the United States Army and eventually with S.T.A.R.S. as its Captain.

Wesker ultimately chose to betray Umbrella and work with other groups to steal its research data, benefiting from a mutation brought on by a prototype virus that gave him superhuman powers. This made him, in his self-assertion, believe that he was chosen to achieve the ultimate goal of causing the mass extinction of humanity in favor of evolution. He was killed in March 2009 during a BSAA operation which uncovered his role in a doomsday project dubbed Uroboros.

Little is known of Wesker's childhood, even his real name. It is understood he inherited advantageous genes relating to intelligence from his parents. Taken from his parents at a young age by agents of Oswell E. Spencer, Earl Spencer, he was raised in one of perhaps several homes funded by the Spencer Foundation. This was to serve as the first stage of a eugenics project, which sought to raise a group of likeminded, gifted intellectuals who could, in the future, be infected with a stabilized variant of the Progenitor Virus and entrusted with its superhuman effects. The children, all named "Wesker" after the project leader, were raised to share Spencer's values, harboring particular disdain for war and pestilence, believing humans to be an evolutionary dead-end in need of order, deliverance and rebirth. In this regard, he stood out before the other Weskers for his absolute ambition in these aspects. To guarantee they reach their potential, each Wesker was raised in an environment that would allow them to receive the best education possible. The children went into different fields of study, with Albert pursuing an education and career in biotechnology.