Befitting the "mad scientist" archetype, Zanzo is an eccentric man who believes himself to be a genius. He is shown many times to be complimenting and awarding his own "brilliant" ideas. In comparison to the other bosses, Zanzo is shown to be the most flashy and flamboyant. Most of his appearances often show him making several gestures and poses to emphasize almost every sentence as if he jumped out of the pages of a manga. Zanzo retains a desire to study as a scientist, but it tends to be overshadowed by his need to be the smartest in the room. He also has a superiority complex, making him susceptible to insults that he perceives from others such as whenever Chai goads him.

Reflecting his own work personality, his own office is extremely messy, from taping design notes to computer screens, to having magazines about fashion and videogames in the same place as top secret documents. Both he and Roquefort don't get along as Roquefort cares about finances, while Zanzo cares about his inventions no matter how much they cost. Though only seen on cutscenes, Zanzo's office has finance statistics scribbled over, implying he believes them to be tampered.