Chitoge Kirisaki (桐崎 千棘, Kirisaki Chitoge), later Chitoge Ichijō (一条 千棘, Ichijō Chitoge) is the ,main female deuteragonist of the Nisekoi series. She is the daughter of Adelt Wogner Kirisaki and Hana Kirisaki who served as the fake girlfriend of Raku Ichijō for the next three years of her school life to prevent a war from starting between their families.
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Kosaki Onodera (小野寺 小咲 Onodera Kosaki), later Kosaki Miyanagi (宮城 小咲, Miyanagi Kosaki), is one of the main characters of the Nisekoi series. She is the daughter of Nanako Onodera, the older sister of Haru Onodera and one of the love interests of Raku Ichijō.

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Marika Tachibana (橘 万里花, Tachibana Marika) is one of the main characters of the Nisekoi series. She is the daughter of Gen Tachibana and Chika Tachibana who is introduced as the fiancé of Raku Ichijō.
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Seishirō Tsugumi (鶫 誠士郎, Tsugumi Seishirō) is a hitman who was raised and trained by Claude Ringheart of the Bee Hive Gang. Tsugumi is originally introduced as a male student who transfers to Chitoge Kirisaki's class and has orders to protect her from Raku Ichijō, whom she thinks forced Chitoge into having a relationship with him.

Tsugumi, although considered a side character in both the manga and anime, has several chapters and episodes dedicated to the development of her relationship with Raku Ichijō.

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Haru Onodera (小野寺 春, Onodera Haru) is the youngest daughter of Nanako Onodera and the younger sister of Kosaki Onodera. She is one of the main supporting protagonists of the Nisekoi series. She is introduced as a freshman, as well as an underclassman of Raku Ichijō and the gang, who would willingly protect her older sister's purity from Raku, whom she thinks of as a womanizing gang member. She is also classmates with Fuu and Paula McCoy.

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Yui Kanakura (奏倉 羽, Kanakura Yui) is a childhood friend of Raku Ichijō as well as his homeroom teacher for at least two trimesters starting from the second year. Yui is also the head of the Chinese mafia group, Char Siu (Chinese: 叉燒, Chāshāo). Yui is also in possession of a fourth key but has confirmed to Raku that she is not the girl he had made a promise with ten years prior.