A few years ago Orichimaru was looking for children with special talents to mark them with a bite and place the curse seal on them, one day he found a perfect girl. Shortly afterwards Orichimaru found Sasuke Uchiha and replaced she with him, and she angrily fled and for not having her seal renewed with another bite and insertion of snake poison she faced severe pain and as a result he gained bicolored eyes. Years later, Orichimaru never imagined that his path would cross hers again.