Eve is the main antagonist of the series Parasite Eve. In actuality Eve has many incarnations all being women who are taken over by the consciousness of awakened mitochondria in themselves, all "Eves" share the goal of eradication of humanity seeking to produce superior organisms who can control their own DNA. One incarnation of Eve awakened in the body of theater actress Melissa Pearce in New York, once dormant in a kidney that was transplanted from Aya Brea's sister during childhood. Eve concocted a plan that the previous Eve in Japan failed to accomplish which was to birth an ultimate being, seeking to be artificially inseminated without male mitochondria.

Eve's appearance while controlling Melissa is only halfway deformed to where her arms are elongated with enlarged sharp claws, beneath the tattered red opera dress she wears and between her legs is a fleshy spiked protrusion akin to a bug abdomen. Her brown flows behind her but is fixated to be pointed and spiked outward similar to horns.

The powers all "Eves" share are abilities such as telepathy, spontaneous combustion and mutations of living organisms in the vicinity, undergoing transformations into mitochondrial beings herself and using her mitochondria to manipulate energy from her body to manifest elements like fire.